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Article

Regulation of Vegf signaling by natural and synthetic ligands.

Blood - 10 Nov 2016

Rossi Andrea, Gauvrit Sebastien, Marass Michele, Pan Luyuan, Moens Cecilia B, Stainier Didier Y R

Abstract excerpt

The mechanisms that allow cells to bypass anti-vascular endothelial growth factor A (VEGFA) therapy remain poorly understood. Here we use zebrafish to investigate this question and first show that vegfaa mutants display a severe vascular phenotype that can surprisingly be rescued to viability by vegfaa messenger RNA injections at the 1-cell stage. Using vegfaa mutants as an in vivo test tube, we found that...

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Source

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Identifiers

PMID: 27557946
DOI: 10.1182/blood-2016-04-711192
PMCID: PMC5766839

Genes

VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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