Article
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish.
Disease models & mechanisms - 1 Jan 2000
van Rooijen Ellen, Voest Emile E, Logister Ive, Bussmann Jeroen, Korving Jeroen, van Eeden Fredericus J, Giles Rachel H, Schulte-Merker Stefan
Abstract excerpt
Biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes human patients to the development of highly vascularized neoplasms in multiple organ systems. We show that zebrafish vhl mutants display a marked increase in blood vessel formation throughout the embryo, starting at 2 days post-fertilization. The most severe neovascularization is observed in distinct areas that overlap with...
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