Article

Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents

2020-08-26

Abstract excerpt

Artemisinin-resistant malaria parasites have emerged and been spreading, posing a significant public health challenge. Anti-malarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a “selective starvation” strategy by selectively inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in Plasmodium falciparum , over human glucose...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 647f5ad0-fc97-51cd-8755-6035f0cb3d15
DOI: 10.1101/2020.08.25.260232

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agentsDOI 10.1101/2020.08.25.260232Read

Molecular docking, simulation and binding free energy analysis of small molecules as <i>Pf</i> HT1 inhibitorsSemantic proximity Read

In silico drug discovery: Unveiling potential targets in Plasmodium falciparumSemantic proximity Read

In Silico Drug Discovery: Unveiling Potential Targets in Plasmodium falciparum through Molecular Docking AnalysisSemantic proximity Read

Title: Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systemsSemantic proximity Read

Design, Synthesis, and Computational Analysis of 4-Amino-1,2,4-Triazol-3-one Schiff Base Derivatives as Potent α-Glucosidase InhibitorsSemantic proximity Read

Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV Pathogen BoxSemantic proximity Read

Driving antimalarial design through understanding of target mechanism.Semantic proximity Read

Targeting Channels and Transporters in Protozoan Parasite InfectionsSemantic proximity Read

Computational studies of drug repurposing targeting P-glycoprotein mediated multidrug-resistance phenotypes in agents of neglected tropical diseasesSemantic proximity Read

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Semantic proximity Read

Identification of potent and selective <i>N</i> -myristoyltransferase inhibitors of <i>Plasmodium vivax</i> liver stage hypnozoites and schizontsSemantic proximity Read

Breaking Glycolysis: Allosteric Hotspots for Multi-Target Drug RepurposingSemantic proximity Read