Article

Design, Synthesis, and Computational Analysis of 4-Amino-1,2,4-Triazol-3-one Schiff Base Derivatives as Potent α-Glucosidase Inhibitors

2026-04-16

Abstract excerpt

<title>Abstract</title> <p> Type 2 diabetes mellitus (T2DM) remains a major global health challenge, driving the search for novel α-glucosidase inhibitors with improved efficacy and safety profiles over existing therapies. Here, we report the design, synthesis, and biological evaluation of a new series of Schiff bases derived from 4-amino-1,2,4-triazol-3(4H)-one (compounds 1–10) as potential antidiabetic agents....

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Literature Corpus work: a143b450-f7d9-5edf-b32d-f4594457bb3b
DOI: 10.21203/rs.3.rs-9242709/v1

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Design, Synthesis, and Computational Analysis of 4-Amino-1,2,4-Triazol-3-one Schiff Base Derivatives as Potent α-Glucosidase InhibitorsDOI 10.21203/rs.3.rs-9242709/v1Read

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