Article

Computational studies of drug repurposing targeting P-glycoprotein mediated multidrug-resistance phenotypes in agents of neglected tropical diseases

2020-06-12

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian ABCB 1 P-glycoprotein is an ATP- dependent efflux pump with broad substrate specificity associated with cellular drug resistance. Homologous to this role in mammalian biology, the P-glycoprotein of agents of neglected tropical diseases (NTDs) mediates the emergence of multidrug-resistance phenotypes. The clinical and socioeconomic implications of NTDs are exacerbated by the lack of re...

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Literature Corpus work: ad073b97-2750-523d-b2ff-4f2e67259488
DOI: 10.1101/2020.06.12.147926

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