Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.

doi:10.1038/s41564-017-0007-4

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Article

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.

Nature microbiology - 1 Oct 2017

Vanaerschot Manu, Lucantoni Leonardo, Li Tao, Combrinck Jill M, Ruecker Andrea, Kumar T R Santha, Rubiano Kelly, Ferreira Pedro E, Siciliano Giulia, Gulati Sonia, Henrich Philipp P, Ng Caroline L, Murithi James M, Corey Victoria C, Duffy Sandra, Lieberman Ori J, Veiga M Isabel, Sinden Robert E, Alano Pietro, Delves Michael J, Lee Sim Kim, Winzeler Elizabeth A, Egan Timothy J, Hoffman Stephen L, Avery Vicky M, Fidock David A

Abstract excerpt

Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapies. Here, we report the identification and characterization of hexahydroquinolines (HHQs) that show low nanomolar potency against both pathogenic and transmissible intra-erythrocytic forms of the malaria parasite Plasmodium falciparum. This activity translates into potent...

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PMID: 28808258
DOI: 10.1038/s41564-017-0007-4
PMCID: PMC5708124

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