Article

Membrane-anchored and tumor-targeted Il-12(attIL12) PBMC therapy for osteosarcoma

2022-03-02

Abstract excerpt

<h4>Background: </h4> Chimeric antigen receptor (CAR) T cell therapy has shown great promise for hematologic malignancies but requires a long duration of T-cell expansion, is associated with severe toxicity, and has limited efficacy for treating solid tumor. Methods To address these challenges, we generated a cell membrane-anchored and tumor-targeted interleukin-12 (attIL12) to arm peripheral blood mononuclear ce...

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Literature Corpus work: 646f4a91-cb6c-51d7-a13e-eb74b9925cce
DOI: 10.21203/rs.3.rs-1392663/v1

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