Article

Tunneling CARs: Increasing CAR T tumor infiltration through the overexpression of <i>MMP7</i> and <i>SPP1</i>

2025-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor T cell (CART) therapy has demonstrated remarkable efficacy in hematologic malignancies but has struggled to achieve comparable success in solid tumors. A key obstacle is the extracellular matrix (ECM) in solid tumors, which significantly impedes CART cell infiltration. In clinical trials, neuroblastoma (NB) has shown responsiveness to GD2-directed CART therapy, however,...

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Identifiers and source

Literature Corpus work: 21621e53-e8f9-5ffa-8b16-dd7f915df0c7
DOI: 10.1101/2025.01.24.634731

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