Article

Highly potent novel multi-armoured IL13Ra2 CAR-T subverts the immunosuppressive microenvironment of Glioblastoma

2025-01-14

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma remains one of the most challenging and lethal brain cancers, with limited treatment options. While CAR-T cells have shown promise in some patients, sustaining T-cell activity and overcoming the immunosuppressive tumour microenvironment remain significant hurdles. Here, we present an armoured CAR-T cell design to address these challenges and enhance persistence in GBM tumours. We dev...

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Literature Corpus work: 51b24475-9506-5805-9ff4-99fa710c26b5
DOI: 10.1101/2025.01.10.632392

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