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Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses

1 Oct 2020

Abstract excerpt

BACKGROUND: Though currently approved immunotherapies, including chimeric antigen receptor T cells and checkpoint blockade antibodies, have been successfully used to treat hematological and some solid tumor cancers, many solid tumors remain resistant to these modes of treatment. In solid tumors, the development of effective antitumor immune responses is hampered by restricted immune cell infiltration and an...

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PMID: 33115946
DOI: 10.1136/jitc-2020-001356

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