Article

Efficient Generation of Functional TCRαβ <sup>+</sup> Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation

2026-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Genetically engineered human induced pluripotent stem cells (hiPSCs) represent a promising platform for regenerative medicine and next-generation immunotherapies. While recent advances enable stroma-free differentiation of hiPSCs into mature CD3⁺TCRαβ⁺ cytotoxic T lymphocytes (CTLs), overall efficiency remains limited. Here, we identify small-molecule modulators that enhance T cell output, parti...

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Literature Corpus work: 38e7239d-203d-5ecf-a731-83cd13ccb7b3
DOI: 10.64898/2026.03.31.715684

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