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Tumor-Specific CD8 <sup>+</sup> T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes

2023-08-29

Abstract excerpt

Immunotherapy is now an integral aspect of cancer therapy. Strategies employing adoptive cell therapy (ACT) have seen the establishment of chimeric antigen receptor (CAR)-T cells using peripheral blood lymphocytes as well as tumor infiltrating lymphocytes (TILs) with significant clinical results. Despite these successes, the limitations of the current strategies are also emerging and novel approaches are needed. T...

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Literature Corpus work
b10373ca-2265-5355-966b-774224390aaf
DOI
10.1101/2023.08.28.555119
Open publication

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Tumor-Specific CD8 <sup>+</sup> T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating LymphocytesDOI 10.1101/2023.08.28.555119
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