Article

The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8 <sup>+</sup> T cell activity and synergizes with immune check-point inhibitors

2019-06-27

Abstract excerpt

<h4>ABSTRACT</h4> We describe the cloning and characterization of a novel fusion protein (termed L19-mIL12), consisting of murine interleukin-12 in single-chain format, sequentially fused to the L19 anti-body in tandem diabody format. The fusion protein bound avidly to the cognate antigen (the alternatively-spliced EDB domain of fibronectin), retained the activity of the parental cyto-kine and was able to selecti...

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Literature Corpus work: d847e4b2-ec4c-56d7-823c-92efa9cd68c5
DOI: 10.1101/684100

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