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Article

A MAPP Network study: overexpression of tumor necrosis factor-α in mouse urothelium mimics interstitial cystitis.

American journal of physiology. Renal physiology - 1 Jul 2018

Yang Wenbin, Searl Timothy J, Yaggie Ryan, Schaeffer Anthony J, Klumpp David J

Abstract excerpt

Interstitial cystitis/bladder pain syndrome is a chronic bladder condition associated with pain and voiding dysfunction that is often regarded as a neurogenic cystitis. Patient symptoms are correlated with the presence of urothelial lesions. We previously characterized a murine neurogenic cystitis model that recapitulates mast cell accumulation and urothelial lesions, and these events were dependent on TNF. To...

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Identifiers

PMID: 29465304
DOI: 10.1152/ajprenal.00075.2017
PMCID: PMC6087793

Genes

TNF

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