Article

Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatability

2021-06-11

Abstract excerpt

<h4>Background: </h4> Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of various chemotherapeutic agents, including oxaliplatin. It is highly prevalent amongst cancer patients, causing sensory abnormalities and pain. Unfortunately, as the underlying mechanisms remain poorly understood, effective therapeutics are lacking. Neuro-immune interactions have been highlighted as potential cont...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1ef54d6-ee4d-575f-b831-7ce9c63ca57f
DOI: 10.12688/wellcomeopenres.16635.2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatabilityDOI 10.12688/wellcomeopenres.16635.2Read

A novel model of paclitaxel-induced peripheral neuropathy produces a clinically relevant phenotype in miceSemantic proximity Read

Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathySemantic proximity Read

Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in miceSemantic proximity Read

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development.Semantic proximity Read

Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights.Semantic proximity Read

Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side EffectSemantic proximity Read

Neurobiology of Cancer Pain: A Narrative ReviewSemantic proximity Read

Circulating microRNA and automated motion analysis as novel methods of assessing chemotherapy-induced peripheral neuropathy in miceSemantic proximity Read

Updates on Oxaliplatin-Induced Peripheral Neurotoxicity (OXAIPN)Semantic proximity Read

Advances in the Pathophysiology and Management of Cancer Pain: A Scoping ReviewSemantic proximity Read

Development and Validation of the Chemotherapy-induced Peripheral Neuropathy Integrated Assessment – Oxaliplatin Subscale: A Prospective Cohort StudySemantic proximity Read

Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathySemantic proximity Read