Article

Macrophages drive the earliest anti-tumoral response to BCG therapy by directly killing bladder cancer through TNF signaling

2024-01-05

Abstract excerpt

<h4>ABSTRACT</h4> The Bacillus Calmette-Guérin (BCG) vaccine is the cancer immunotherapy longest in use. Despite its effectiveness in bladder cancer (BC), its initial mechanisms of action remain largely unknown. Therefore, proper diagnostic assessments to identify patients who will not respond to treatment or develop resistance are lacking. Here, we set-out to unravel the earliest innate cellular mechanisms invol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93578d06-528c-579d-9396-dde98509e123
DOI: 10.1101/2024.01.05.574391

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Macrophages drive the earliest anti-tumoral response to BCG therapy by directly killing bladder cancer through TNF signalingDOI 10.1101/2024.01.05.574391Read

Targeting CXCR4-expressing TAMs in muscle-invasive bladder cancer to enhance tumor control after immunotherapySemantic proximity Read

Microbial cancer immunotherapy reprograms hematopoiesis to enhance anti-tumor immunitySemantic proximity Read

Treatment of non-muscle invasive bladder cancer with Bacillus Calmette–Guerin (BCG): Biological markers and simulation studiesSemantic proximity Read

Dynamic CD8+ T Cell Cooperation with Macrophages and Monocytes for Successful Cancer ImmunotherapySemantic proximity Read

Increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages associate with poor clinical outcomes in BCG treated non-muscle invasive bladder cancerSemantic proximity Read

Type III interferon inhibits bladder cancer progression by reprogramming macrophage-mediated phagocytosis and orchestrating effective immune responsesSemantic proximity Read

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumorsSemantic proximity Read

Phenotypic characterization of tumor associated macrophages and circulating monocytes in patients with Urothelial carcinoma of bladder.Semantic proximity Read

Tumor-associated macrophage enhances PD-L1-mediated immune escape of bladder cancer through PKM2 dimer/STAT3 complex nuclear translocationSemantic proximity Read

CAR-MACROPHAGES ACTIVATE ANTI TUMOR T CELLS IN THE ABSENCE OF PHAGOCYTOSISSemantic proximity Read

M2 Macrophage Co-Expression Factors Correlate With Immune Phenotype and Predict Prognosis of Bladder CancerSemantic proximity Read

B cell exhaustion associates with poor response to Bacillus Calmette-Guérin immunotherapy in patients with bladder cancerSemantic proximity Read