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Article

MEIS2 regulates endothelial to hematopoietic transition of human embryonic stem cells by targeting TAL1

1 Dec 2018

Abstract excerpt

BACKGROUND: Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells from human embryonic stem cells (hESCs) is still unsuccessful. Therefore, a better understanding of the molecular mechanism underlying hematopoietic differentiation of hESCs is highly demanded....

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PMID: 30526668
DOI: 10.1186/s13287-018-1074-z

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