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Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium

17 Jul 2023

Abstract excerpt

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of haemogenic endothelial cells in the aorta-gonad-mesonephros (AGM). HSPCs in the AGM are heterogeneous in differentiation and proliferative output, but how these intrinsic differences are acquired remains unanswered. Here we discovered that loss...

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PMID: 37460694
DOI: 10.1038/s41556-023-01187-9

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