Article

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexes

2023-08-09

Abstract excerpt

<h4>ABSTRACT</h4> With the importance of Hedgehog signalling in embryonic development, tissue homeostasis and disease, understanding the molecular mechanisms of signal transduction is paramount for the design of specific, effective therapeutics. The Hedgehog receptor PTCH1 and the less studied PTCH2 isoform are evolutionarily related to bacterial RND permeases and sterol sensing proteins, which mobilise hydrophob...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 643c4fd4-485a-5827-aefb-9c581d74ef58
DOI: 10.1101/2023.08.08.549832

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexesDOI 10.1101/2023.08.08.549832Read

Structural basis of sterol recognition by human hedgehog receptor PTCH1Semantic proximity Read

Characterization of two patched receptors for the vertebrate hedgehog protein familySemantic proximity Read

Genetic and biochemical definition of the Hedgehog receptor.Semantic proximity Read

Non-cell autonomous inhibition of the Hedgehog response due to impaired cholesterol synthesis requires Ptch1/2 functionSemantic proximity Read

Nanoscale organization of hedgehog is essential for long-range signaling.Semantic proximity Read

Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype.Semantic proximity Read

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.Semantic proximity Read

Ptch2 mediates the Shh response in Ptch1-/- cells.Semantic proximity Read

The hedgehog signaling network.Semantic proximity Read

Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.Semantic proximity Read

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteSemantic proximity Read

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Semantic proximity Read