Article

Structural basis of sterol recognition by human hedgehog receptor PTCH1

2018-12-30

Abstract excerpt

Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4 Å cryo-EM structure of the human PTCH1 bound to ShhN C24II , a modified hedgehog ligand mimicking its palmitoylated form. The...

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Literature Corpus work: 2ab51c87-784b-5030-886a-5206d012fb69
DOI: 10.1101/508325

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