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Article

Dynamic STING repression orchestrates immune cell development and function

7 Mar 2025

Abstract excerpt

STING is an essential component of the innate immune system, yet homeostatic STING expression patterns and regulation are unknown. Using Sting1 IRES-EGFP reporter and conditional Sting1 transgenic mice, we found that regulation of STING expression is critical for immune cell development and functionality. STING expression was repressed in neutrophils, and forced STING expression or signaling drove systemic...

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PMID: 40053603
DOI: 10.1126/sciimmunol.ado9933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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