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Article

Abnormalities of T cell signaling in systemic lupus erythematosus

1 Jan 2011

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, leading to tissue damage. Abnormal...

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PMID: 21457530
DOI: 10.1186/ar3251

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