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4-Octyl Itaconate promotes dendritic cell tolerogenic properties via suppressing STING signaling to delay lupus onset

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Systemic lupus erythematosus (SLE) is a refractory autoimmune disease characterized by immune tolerance breakdown and dendritic cell (DCs) hyperactivation. Tolerogenic DCs (tolDCs) represent a promising therapeutic strategy, yet the regulatory mechanisms remain poorly understood. Here, we investigated the therapeutic potential and mechanism of the 4-octyl itaconate (4OI) and 4OI-induced...

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Literature Corpus work
d44ef5cf-a2a6-5c03-8f4e-08808c1ec6eb
DOI
10.21203/rs.3.rs-9575020/v1
Open publication

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4-Octyl Itaconate promotes dendritic cell tolerogenic properties via suppressing STING signaling to delay lupus onsetDOI 10.21203/rs.3.rs-9575020/v1
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