The IL‐12‐STAT4 axis in the pathogenesis of human systemic lupus erythematosus

Abstract excerpt

Abstract Generation of autoantibodies is a hallmark of systemic lupus erythematosus (SLE). As demonstrated in a number of lupus mouse models, recent evidence suggests that both GC and extrafollicular pathways contribute to the generation of autoantibodies also in human SLE, and that CD11c+ IgD−CD27−(double negative:DN) B cells play a central role in the latter pathway. In this mini‐review, the author will first...

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