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Regulation of cGAS-STING pathway - Implications for systemic lupus erythematosus

1 Sept 2021

Abstract excerpt

Type I interferon (IFN-I) is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and the closely associated monogenic autoinflammatory disorders termed the "interferonopathies." Recently, the cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have been identified as having...

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PMID: 36465073
DOI: 10.2478/rir-2021-0023

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