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Article

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

PloS one - 1 Jan 2011

Sheridan Steven D, Theriault Kraig M, Reis Surya A, Zhou Fen, Madison Jon M, Daheron Laurence, Loring Jeanne F, Haggarty Stephen J

Abstract excerpt

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. In addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social difficulties, anxiety, and other autistic-like behaviors. FXS is caused by an expanded CGG trinucleotide repeat in the 5' untranslated region of the Fragile X Mental Retardation (FMR1) gene leading to epigenetic silencing and loss...

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Identifiers

PMID: 22022567
DOI: 10.1371/journal.pone.0026203
PMCID: PMC3192166

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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