Article
Chromothripsis is a frequent event and underlies typical genetic changes in early T-cell precursor lymphoblastic leukemia in adults.
Leukemia - 1 Nov 2022
Arniani Silvia, Pierini Valentina, Pellanera Fabrizia, Matteucci Caterina, Di Giacomo Danika, Bardelli Valentina, Quintini Martina, Mavridou Elena, Lema Fernandez Anair Graciela, Nardelli Carlotta, Moretti Martina, Gorello Paolo, Crescenzi Barbara, Romoli Silvia, Beacci Donatella, Cerrano Marco, Fracchiolla Nicola, Sica Simona, Forghieri Fabio, Giglio Fabio, Dargenio Michela, Elia Loredana, La Starza Roberta, Mecucci Cristina
Abstract excerpt
Chromothripsis is a mitotic catastrophe that arises from multiple double strand breaks and incorrect re-joining of one or a few chromosomes. We report on incidence, distribution, and features of chromothriptic events in T-cell acute lymphoblastic leukemias (T-ALL). SNP array was performed in 103 T-ALL (39 ETP/near ETP, 59 non-ETP, and 5 with unknown stage of differentiation), including 38 children and 65 adults....
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