Article

Accounting for age-of-onset and family history improves power in genome-wide association studies

2021-04-21

Abstract excerpt

Genome-wide association studies (GWAS) have revolutionized human genetics, allowing researchers to identify thousands of disease-related genes and possible drug targets. However, case-control status does not account for the fact that not all controls may have lived through their period of risk for the disorder of interest. This can be quantified by examining the age-of-onset distribution and the age of the control...

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Literature Corpus work: 63f3fd07-5b46-5019-81e1-bb22cbbe12c6
DOI: 10.1101/2021.04.20.440585

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