Article

Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

2022-03-31

Abstract excerpt

Genome-wide association studies seek to attribute disease risk to DNA regions and facilitate subject-specific prediction and patient stratification. For later-life diseases, inference from case-control studies is hampered by the uncertainty that control group subjects might later be diagnosed. Time-to-event analysis treats controls as right-censored, making no additional assumptions about future disease occurrence...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb0a4158-536d-5bc6-92d5-8311123ba0dd
DOI: 10.1101/2022.03.25.22272955

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onsetDOI 10.1101/2022.03.25.22272955Read

Findings and insights from the genetic investigation of age of first reported occurrence for complex disorders in the UK Biobank and FinnGenSemantic proximity Read

Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysisSemantic proximity Read

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk predictionSemantic proximity Read

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.Semantic proximity Read

Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis.Semantic proximity Read

Gene-level heritability analysis explains the polygenic architecture of cancerSemantic proximity Read

Cancer Diagnosis, Polygenic Risk, and Longevity-Associated VariantsSemantic proximity Read

The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.Semantic proximity Read

Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study.Semantic proximity Read

The impact of age on genetic risk for common diseasesSemantic proximity Read

Germline Variation and Breast Cancer Incidence: A Gene-Based Association Study and Whole-Genome Prediction of Early-Onset Breast Cancer.Semantic proximity Read

Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.Semantic proximity Read