Article

Findings and insights from the genetic investigation of age of first reported occurrence for complex disorders in the UK Biobank and FinnGen

2020-11-25

Abstract excerpt

Age of onset contains information on the timing of events relevant to disease etiology, but there has not been a systematic investigation of its heritability from GWAS data. Here, we characterize the genetic architecture of age of first occurrence and its genomic relationship with disease susceptibility for a wide range of complex disorders in the UK Biobank. For diseases with a sufficient sample size, we discover...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d6ea42b-7ffa-5989-9180-7cabe1ca360c
DOI: 10.1101/2020.11.20.20234302

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Findings and insights from the genetic investigation of age of first reported occurrence for complex disorders in the UK Biobank and FinnGenDOI 10.1101/2020.11.20.20234302Read

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancersSemantic proximity Read

The impact of age on genetic risk for common diseasesSemantic proximity Read

Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onsetSemantic proximity Read

The impact of age on genetic risk for common diseasesSemantic proximity Read

Systematic comparison of family history and polygenic risk across 24 common diseasesSemantic proximity Read

Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort.Semantic proximity Read

Uncovering the Heritable Components of Multimorbidities and Disease Trajectories: A Nationwide Cohort StudySemantic proximity Read

Systematic comparison of family history and polygenic risk across 24 common diseases.Semantic proximity Read

Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis.Semantic proximity Read

Exposure accumulation drives age-dependent disease architectures and polygenic risk scoresSemantic proximity Read

Common genetic associations between age-related diseasesSemantic proximity Read

A time-to-event heritability framework for inferring the genetic architecture of longitudinal traitsSemantic proximity Read