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Article

Accounting for age of onset and family history improves power in genome-wide association studies.

American journal of human genetics - 3 Mar 2022

Pedersen Emil M, Agerbo Esben, Plana-Ripoll Oleguer, Grove Jakob, Dreier Julie W, Musliner Katherine L, Bækvad-Hansen Marie, Athanasiadis Georgios, Schork Andrew, Bybjerg-Grauholm Jonas, Hougaard David M, Werge Thomas, Nordentoft Merete, Mors Ole, Dalsgaard Søren, Christensen Jakob, Børglum Anders D, Mortensen Preben B, McGrath John J, Privé Florian, Vilhjálmsson Bjarni J

Abstract excerpt

Genome-wide association studies (GWASs) have revolutionized human genetics, allowing researchers to identify thousands of disease-related genes and possible drug targets. However, case-control status does not account for the fact that not all controls may have lived through their period of risk for the disorder of interest. This can be quantified by examining the age-of-onset distribution and the age of the...

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Identifiers

PMID: 35139346
DOI: 10.1016/j.ajhg.2022.01.009
PMCID: PMC8948165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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