Article
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology - 1 Jan 2019
Fenninger Franz, Han Jeffrey, Stanwood Shawna R, Nohara Lilian L, Arora Hitesh, Choi Kyung Bok, Munro Lonna, Pfeifer Cheryl G, Shanina Iryna, Horwitz Marc S, Jefferies Wilfred A
Abstract excerpt
Calcium (Ca2+) is a vital secondary messenger in T lymphocytes regulating a vast array of important events including maturation, homeostasis, activation, and apoptosis and can enter the cell through CRAC, TRP, and CaV channels. Here we describe a mutation in the L-type Ca2+ channel CaV1.4 leading to T lymphocyte dysfunction, including several hallmarks of immunological exhaustion. CaV1.4-deficient mice exhibited...
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