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Article

T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling?

The Biochemical journal - 1 Aug 1998

Hirota J, Baba M, Matsumoto M, Furuichi T, Takatsu K, Mikoshiba K

Abstract excerpt

Stimulation of T-cells via the T-cell receptor (TCR) complex is accompanied by an increase in intracellular Ca2+ concentration ([Ca2+]i). Recently, it was reported that a stable transformant of the human T-cell line, Jurkat, expressing an antisense cDNA construct of inositol 1,4,5-trisphosphate r...

Topics

Animals
Bone Marrow Transplantation
Calcium
Calcium Channels
Cell Survival
Female
Inositol 1,4,5-Trisphosphate Receptors
Lymphocyte Activation
Male
Mice
Mice, Inbred C57BL
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

Receptors, Cytoplasmic and Nuclear

Signal Transduction

T-Lymphocytes

Whole-Body Irradiation

Source

Open in PubMed Open full text

Identifiers

PMID: 9677320
DOI: 10.1042/bj3330615
PMCID: PMC1219624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9677320-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling?PMID 9677320Read ↗

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