Article

Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

2025-03-31

Abstract excerpt

Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including genes affected by rare high-penetrance single nucleotide variants (SNVs) and copy number variants (CNVs). ASD and SCZ exhibit both overlapping and distinct clinical phenotypes. Cognitive deficits and intellectual disability—critical predictors of long-term outcomes—are common to both cond...

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Literature Corpus work: 63eb6401-8195-59a7-98b4-1852ebada0b6
DOI: 10.1101/2025.03.28.645799

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