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Deficiency of intellectual disability-related gene <i>Brpf1</i> reduced inhibitory neurotransmission and <i>Map2k7</i> expression in GABAergic interneurons

2021-01-12

Abstract excerpt

Intellectual disability is closely related to impaired GABA neurotransmission. Brpf1 was specifically expressed in medial ganglionic eminence (MGE), a developmental niche of GABAergic interneurons, and patients with BRPF1 mutations were mentally retarded. To test its role in development and function of MGE-derived GABAergic interneurons, we performed immunofluorescence staining, whole-cell patch-clamp, MGE trans...

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Literature Corpus work
6a8cce70-0bd4-55c4-b5a8-d20d7343d185
DOI
10.1101/2021.01.11.426233
Open publication

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Deficiency of intellectual disability-related gene <i>Brpf1</i> reduced inhibitory neurotransmission and <i>Map2k7</i> expression in GABAergic interneuronsDOI 10.1101/2021.01.11.426233
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