Article

Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice

2024-04-30

Abstract excerpt

Individuals with the 22q11.2 deletion syndrome, one of the strongest genetic risk factors for schizophrenia, demonstrate cognitive impairments, including episodic memory dysfunction. Place cell activity of excitatory pyramidal neurons in the hippocampus supporting episodic memory is impaired in a mouse model for the 22q11.2 deletion ( Df(16)A +/- ). While excitatory dynamics are under tight inhibitory control by...

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Literature Corpus work: dfc61ce5-12ac-5369-83be-6c5355a5dc8a
DOI: 10.1101/2024.04.28.591464

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