Article

Effects of Spin4 ablation in aging mice: body composition, bone density, and malignancy prevalence

2026-02-08

Abstract excerpt

Many overgrowth syndromes are associated with increased risk of tumorigenesis and malignancies. Our group recently identified a frameshift variant in histone reader SPIN4 located on the X chromosome to be a new genetic cause for human overgrowth. In the current study, we investigated the prevalence of malignancies, along with body weight, body length, body composition and bone mineral density, in Spin4 knockout m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7715d201-651a-541a-b50c-618a1c9ae7db
DOI: 10.64898/2026.02.05.704000

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of Spin4 ablation in aging mice: body composition, bone density, and malignancy prevalenceDOI 10.64898/2026.02.05.704000Read

Epigenetic Causes of Overgrowth SyndromesSemantic proximity Read

Novel mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibitionSemantic proximity Read

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide <i>Myc</i> InactivationSemantic proximity Read

Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivationSemantic proximity Read

SPIN4-related X-linked overgrowth in a family.Semantic proximity Read

Genetic Loci and Metabolic States Associated With Murine Epigenetic AgingSemantic proximity Read

Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability.Semantic proximity Read

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.Semantic proximity Read

Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptorSemantic proximity Read

Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas.Semantic proximity Read

The Myc-Like Mlx Network Impacts Aging and MetabolismSemantic proximity Read

Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammationSemantic proximity Read