Article
Integrated single-cell RNA-seq analysis identifies immune heterogeneity associated with KRAS/TP53 mutation status and tumor-sideness in colorectal cancers.
Frontiers in immunology - 1 Jan 2022
Liu Xiaoyu, Xu Xu, Wu Zhuozhuo, Shan Qungang, Wang Ziyin, Wu Zhiyuan, Ding Xiaoyi, Huang Wei, Wang Zhongmin
Abstract excerpt
Background: The main objective of this study was to analyze the effects of KRAS/TP53 mutation status and tumor sideness on the immune microenvironment of colorectal cancer using integrated scRNA-seq data. Methods: A total of 78 scRNA-seq datasets, comprising 42 treatment-naive colorectal tumors, 13 tumor adjacent tissues and 23 normal mucosa tissues were included. Standardized Seurat procedures were applied to...
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