Article

CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression

2024-01-15

Abstract excerpt

<title>Abstract</title> Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men, and treatment options for metastatic disease remain limited. In this study, we employed Adeno-associated virus (AAV) delivery and CRISPR-Cas9 technology to simultaneously mutate multiple genes in the mouse prostate, in order to investigate positive genetic interactions during PCa progression. By targeting...

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Literature Corpus work: af465d12-5bdb-5f71-96f4-7f0dd7839c37
DOI: 10.21203/rs.3.rs-3013972/v1

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