Article
Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.
Neuropathology and applied neurobiology - 1 Dec 2017
Son M-Y, Sim H, Son Y S, Jung K B, Lee M-O, Oh J-H, Chung S-K, Jung C-R, Kim J
Abstract excerpt
AIMS: The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common genetic cause of Parkinson's disease (PD). There is compelling evidence that PD is not only a brain disease but also a gastrointestinal disorder; nonetheless, its pathogenesis remains unclear. We aimed to develop human neural and intestinal tissue models of PD patients harbouring an LRRK2 mutation to understand the link between...
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