Article

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS

2025-12-12

Abstract excerpt

<h4>SUMMARY</h4> Oligodendrocytes, the second most abundant cell type in the motor cortex and the most abundant in the spinal cord—are increasingly recognized as active contributors to neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Yet their diversity and disease relevance in the central nervous system remain incompletely defined. Here, we generate a comprehensive single-nucleus transc...

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Literature Corpus work: c549b391-b134-561b-821a-01151526ab0b
DOI: 10.64898/2025.12.09.693234

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