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Article

Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome

1 Mar 2022

Abstract excerpt

Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing parvalbumin GABAergic interneurons (PV-INs) from young Scn1a +/− mice show impaired action potential generation. An approach assessing PV-IN function in the same mice at two time...

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PMID: 35354025
DOI: 10.1016/j.celrep.2022.110580

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