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Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in <i>SCN8A</i> Epileptic Encephalopathy

2024-02-10

Abstract excerpt

SCN8A epileptic encephalopathy (EE) is a severe epilepsy syndrome resulting from de novo mutations in the voltage-gated sodium channel Na v 1.6, encoded by the gene SCN8A . Na v 1.6 is expressed in both excitatory and inhibitory neurons, yet previous studies have primarily focused on the impact SCN8A mutations have on excitatory neuron function, with limited studies on the importance of inhibitory interneuron...

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Literature Corpus work
02d0e405-4d5d-554a-ae4d-27d3c9b8b4a9
DOI
10.1101/2024.02.09.579511
Open publication

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Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in <i>SCN8A</i> Epileptic EncephalopathyDOI 10.1101/2024.02.09.579511
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