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Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons

18 Sept 2023

Abstract excerpt

Abstract N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits ( GRIN1 ) and two GluN2 subunits ( GRIN2A - GRIN2D ). Sequencing data shows that 43% (297/679) of all currently known NMDAR disease-associated genetic variants are...

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PMID: 37723282
DOI: 10.1038/s42003-023-05298-9

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