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Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome

2024-10-02

Abstract excerpt

Dravet syndrome is caused by heterozygous loss-of-function variants in SCN1A , which encodes the voltage-gated sodium channel Nav1.1. Our recent work suggests that a primary pathogenic mechanism of Dravet syndrome is impaired action potential propagation along axons of cortical parvalbumin-positive fast-spiking GABAergic interneurons (PVINs). Ectopic action potentials (EAPs) are action potentials that initiate di...

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Literature Corpus work
2f165396-6a9b-5afe-a832-40090f43ab02
DOI
10.1101/2024.09.30.615811
Open publication

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Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet SyndromeDOI 10.1101/2024.09.30.615811
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