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Loss of <i>Grin2a</i> Causes a Transient Delay in the Electrophysiological Maturation of Hippocampal Parvalbumin Interneurons: A Possible Mechanism for Transient Seizure Burden in Patients with Null <i>GRIN2A</i> Variants

2021-12-29

Abstract excerpt

N-methyl-D-aspartate receptors (NMDARs) comprise a family of ligand-gated ionotropic glutamate receptors that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (encoded by the GRIN1 gene) and two GluN2 subunits (encoded by the GRIN2A - GRIN2D genes). Sequencing data shows that 43% (297/679) of all currently known NMD...

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Literature Corpus work
2a29cfe7-2428-5a3e-8da6-874465c6731e
DOI
10.1101/2021.12.29.474447
Open publication

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Loss of <i>Grin2a</i> Causes a Transient Delay in the Electrophysiological Maturation of Hippocampal Parvalbumin Interneurons: A Possible Mechanism for Transient Seizure Burden in Patients with Null <i>GRIN2A</i> VariantsDOI 10.1101/2021.12.29.474447
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