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Article

Stabilizing selection of protein function and distribution of selection coefficient among sites.

Genetica - 1 May 2007

Gu Xun

Abstract excerpt

In this study, I take a new approach to modeling the evolutionary constraint of protein sequence, introducing the stabilizing selection of protein function into the nearly-neutral theory. In other words, protein function under stabilizing selection generates the evolutionary conservation at the sequence level. With the help of random mutational effects of nucleotides on protein function, I have derived the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17077960
DOI: 10.1007/s10709-006-0022-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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