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Near Neutral Selectionist Theories (NNST) for SARS-CoV-2 suggested by the substitution-mutation ratio (c/µ) analysis.

PloS one - 1 Jan 2026

Wu Chun, Paradis Nicholas J

Abstract excerpt

A definitive test to measure genome-wide fitness effects of any nucleotide mutation, including translated regions (TRs) and untranslated regions (UTRs), is essential to help resolve the decades-long neutralist-selectionist debate regarding mutation-mediated species evolution. The precise boundary, composition, and abundance of nearly neutral mutations remain disputed, highlighting the need for a rigorous...

Topics

Selection, Genetic
SARS-CoV-2
Mutation
Mutation Rate
COVID-19
Evolution, Molecular
Humans
Genome, Viral
Models, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41779771
DOI: 10.1371/journal.pone.0343410
PMCID: PMC12959723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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