Article

The effect of known mutator alleles in a cluster of clinical <i>Saccharomyces cerevisiae</i> strains

2016-11-30

Abstract excerpt

Natural selection has the potential to act on all phenotypes, including genomic mutation rate. Classic evolutionary theory predicts that in asexual populations, mutator alleles, which cause high mutation rates, can fix due to linkage with beneficial mutations. This phenomenon has been demonstrated experimentally and may explain the frequency of mutators found in bacterial pathogens. In contrast, in sexual populati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63ba6d28-a8f6-53e5-b10f-6ecb90820470
DOI: 10.1101/090498

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The effect of known mutator alleles in a cluster of clinical <i>Saccharomyces cerevisiae</i> strainsDOI 10.1101/090498Read

Known mutator alleles do not markedly increase mutation rate in clinical Saccharomyces cerevisiae strains.Semantic proximity Read

Mismatch Repair Incompatibilities in Diverse Yeast Populations.Semantic proximity Read

Mutator dynamics in sexual and asexual experimental populations of yeast.Semantic proximity Read

Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates.Semantic proximity Read

The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae.Semantic proximity Read

Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.Semantic proximity Read

Roles of Mutation, Ploidy, and Recombination in Adaptive Evolution in Divergent Model Yeasts <em>Saccharomyces cerevisiae</em> and the Human Pathogenic <em>Cryptococcus</em>Semantic proximity Read

Ploidy controls the success of mutators and nature of mutations during budding yeast evolution.Semantic proximity Read

Multiplexing Mutation Rate Assessment: Determining Pathogenicity of Msh2 Variants in <i>S. cerevisiae</i>Semantic proximity Read

The balance between mutators and nonmutators in asexual populations.Semantic proximity Read

Contingency loci, mutator alleles, and their interactions. Synergistic strategies for microbial evolution and adaptation in pathogenesis.Semantic proximity Read

DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae.Semantic proximity Read