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Article

Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates.

PLoS genetics - 20 Jun 2008

Demogines Ann, Wong Alex, Aquadro Charles, Alani Eric

Abstract excerpt

Genetic background effects underlie the penetrance of most genetically determined phenotypes, including human diseases. To explore how such effects can modify a mutant phenotype in a genetically tractable system, we examined an incompatibility involving the MLH1 and PMS1 mismatch repair genes using a large population sample of geographically and ecologically diverse Saccharomyces cerevisiae strains. The mismatch...

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Source

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Identifiers

PMID: 18566663
DOI: 10.1371/journal.pgen.1000103
PMCID: PMC2413424

Genes

MLH1
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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